Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including multiple myeloma, mantle cell lymphoma, and del 5q myelodysplastic syndromes in vitro. On february 22, the food and drug administration fda approved a new use for the drug lenalidomide revlimid in treating patients with multiple myeloma under the new approval, patients with multiple myeloma can receive lenalidomide as maintenance therapy after receiving an autologous stem cell transplant for the disease, to help keep the cancer from coming back. May be harmful by inhalation, ingestion, or skin absorption. Lenalidomide side effects, dosage, interactions drugs. If lenalidomide is used during pregnancy, it may cause birth defects or death to a developing baby.
Although the exact mechanism of action is unknown, lenalidomide also has antiinflammatory and anticancer properties. Lenalidomide, a teratogenic thalidomidelike drug figure 1. Information about the revlimid rems program is available at. Report any suspected fetal exposure to lenalidomide to the fda via the medwatch program at 1800fda1088 and also to the manufacturer at 18884235436. Celgene, expanding its use, in combination with lowdose dexamethasone, for the firstline treatment of patients with newly diagnosed multiple myeloma. In studies of both healthy volunteers and subjects with hansens disease, the mean. This study evaluated continuous lenalidomide in combination with. Hematologic toxicity revlimid can cause significant neutropenia and thrombocytopenia 5. This emedtv page takes a look at what else the drug is used for and explains how it works. Rechallenge with lenalidomide is reasonable in patients who do not have a severe rash and will often allow continued treatment. Revlimid cost lenalidomide posted by mitch fraker see editorial guidelines is your revlimid medication too expensive.
Australian public assessment report for lenalidomide tga. Lenalidomide, a thalidomide analogue, caused limb abnormalities in a developmental monkey study. Lenalidomide and dexamethasone are usually taken at home. Advise patient that they cannot donate blood and male patients cannot donate sperm while taking lenalidomide. Male patients receiving lenalidomide must always use a latex condom during and for up to 28 days following discontinuation during any contact with females with childbearing potential, even if they have undergone a successful vasectomy.
It is used to treat multiple myeloma, certain types of lymphoma, and some myelodysplastic syndromes that cause severe anemia requiring blood transfusions. Lenalidomide definition of lenalidomide by medical dictionary. Lenalidomide is a chemotherapy drug that targets specific proteins within cancer cells and stops the cancer cell from growing. Because of the potential for adverse reactions in breastfed infants from lenalidomide, advise women not to breastfeed during treatment. It selectively inhibits secretion of inflammatory cells, enhances the activity of immunity. In other words, metoo drugs are not truly innovative or. Nov 07, 2019 to avoid embryofetal exposure to lenalidomide, revlimid is only available through a restricted distribution program, the revlimid rems program 5. Kyprolis carfilzomib is indicated in combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy. It is a more potent molecular analog of thalidomide, which inhibits tumor angiogenesis, tumorsecreted cytokines, and tumor proliferation through induction of apoptosis. The tale of lenalidomide clinical superiority over thalidomide and.
This includes your doctors, nurses, pharmacists, and dentists. To avoid embryofetal exposure to lenalidomide, revlimid is only available through a restricted distribution program, the revlimid remstm program formerly known as the revassist program 5. Practical guide to management of lenalidomiderelated rash in. Rationale for inclusion in pa program background revlimid is classed as an immunomodulator and is a chemical derivative of thalidomide. Other important lenalidomide warnings and precautions are outlined in this article, with details on what your doctor needs to know. Side effects of revlimid lenalidomide, warnings, uses. Nphthalimido glutarimide, is an immunomodulatory agent. Do not donate blood while using lenalidomide and for 1 month after stopping. Email article add to my reading list export citation create citation alert. Lenalidomide, despite its known toxicities, has significantly improved the oncepoor prognosis and survival rates of mm. Nov 09, 2018 lenalidomide can increase the risk of death from serious heart problems in people with cll. Lenalidomide is an immunomodulator, a structural and functional analogue of thalidomide. Material may be irritating to the mucous membranes and upper respiratory tract. He held on to the words treatable when i held on to the words incurable.
Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Not known whether lenalidomide is present in semen. Practical guide to management of lenalidomiderelated rash. Pdf lenalidomideinduced high grade fever in a patient with. In order to decrease the risk of embryofetal exposure, lenalidomide is available only through a restricted distribution program revlimid rems bortezomib is usually given in an outpatient infusion center, allowing the person to go home afterwards. To avoid embryofetal exposure to lenalidomide, revlimid is only available through a restricted distribution program, the revlimid rems program 5. The tale of lenalidomide clinical superiority over. On february 18, 2015, the us food and drug administration fda approved a new indication for lenalidomide revlimid. However, the capsules are 90% bioavailable relative to an oral peg solution. Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. See full prescribing information for complete boxed warning. How to fill a revlimid lenalidomide prescription 1. A treatment option for multiple myeloma revlimid lenalidomide.
Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling. If you are a man, do not donate sperm while using lenalidomide and for 1 month after stopping. The absolute bioavailability of thalidomide from thalomid thalidomide capsules has not yet been characterized in human subjects due to its poor aqueous solubility. Provide you with information about lenalidomide as a treatment for myeloma.
Are you looking for a place to get your revlimid lenalidomide medication at an affordable price. Kyprolis carfilzomib for relapsed or refractory multiple. Revlimid is also used in patients with myelodysplastic syndrome and may also be used for other purposes not listed. Lenalidomide must be discontinued for angioedema, grade 4 rash, and exfoliative or bullous rash, or if stevensjohnson syndrome or. For patients with del 5q myelodysplastic syndromes, monitor complete blood counts weekly for the first 8 weeks and monthly thereafter 5. Realworld analysis of celgene global drug safety database. Lenalidomide safety data sheet supersedes revision. Hcp provides authorization number on patient prescription form 6. While they remain to be fully characterized, multiple mechanisms of action have been identified, including increasing hemoglobin expression. Find patient medical information for lenalidomide oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Revlimid lenalidomide is a prescription medicine, used to treat adults with multiple myeloma mm in combination with the medicine dexamethasone, or as maintenance treatment after autologous hematopoietic stem cell transplantation a type of stem cell transplant that uses your own stem cells.
Lenalidomide approved as firstline therapy in multiple myeloma. Ic50 nm 1 in vitro lenalidomide strongly induces il2 and sil2r production. Revlimid in combination with dexamethasone is indicated for the treatment of adult patients with multiple myeloma mm. Multiple myeloma is a cancer of plasma cells in the bone marrow that often leads to bone destruction and bone marrow failure. Lenalidomideinduced tyrosine phosphorylation of cd28 on t cells is followed by a downstream activation of nf. The pi also includes unchanged dose adjustments in patients with mm and mds if treatment is associated with other grade 34 toxicities and. Revlimid lenalidomide dosing, indications, interactions. Pediatric and y oung a dult rr bc ell all up to 25 years of age. Lenalidomide is available only from a certified pharmacy under a special program called revlimid rems. The empirical formula for thalidomide is ch10n2o4 and the gram molecular weight is 258. Oct 16, 2019 tell all of your health care providers that you take lenalidomide.
First aid measures description of first aid measures. Rvd or vrd treatment for multiple myeloma chemoexperts. Learn more about revlimid, a treatment option for multiple myeloma. Pdf on may 20, 2018, ajai chari and others published daratumumab dara in combination with carfilzomib and dexamethasone dkd in lenalidomide lenrefractory patients pts with relapsed.
As this emedtv web page explains, lenalidomide should not be used in pregnant women or people who have certain allergies. Highlights of prescribing information these highlights. Revlimid lenalidomide side effects, images, uses, dosage. Males, including those who have had a vasectomy, must always use a latex or synthetic condom during any sexual contact with a pregnant female or a female that can become pregnant while taking revlimid, during any breaks interruptions in your treatment with revlimid, and for up to 4 weeks after stopping. Lenalidomide, a thalidomide analogue, caused limb abnormalities in. Drug administration fda in june 2006 for use in myeloma patients who. Pdf daratumumab dara in combination with carfilzomib. Jun 06, 2019 what are the possible side effects of lenalidomide revlimid. Lenalidomide is effective at inducing a complete or very good partial response and improves progressionfree survival. Thalidomide is a known human teratogen that causes severe lifethreatening human birth defects. Lenalidomide is prescribed to slow down the progression of multiple myeloma and myelodysplastic syndrome. Healthcare provider hcp instructs female patients to complete initial patient survey 2. Revlimid lenalidomide is a prescription medicine approved in combination with dexamethasone to treat patients with multiple myeloma a type of cancer of the bone marrow who already have had. Revlimid lenalidomide now fda approved as firstline.
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